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Dr. Sandra Lee helps Melissa who has tried to cover a huge lipoma with a sweatshirt for years. Tyler's fear of cancer has kept him from having his huge head lumps diagnosed, Tahj is covered in painful boils and Amber has ear keloids that have taken control of her life.

Dr. Sandra Lee assists patients including Ronen whose mysterious lump above his knee is one of the largest she has ever seen. Amber suffers from a debilitating skin disease that no one understands, Sandy has a neck lump she has named Tommy and Kristy's eyelid cyst is ruining her life.

Half of Mary's body is a size 18 while the other is an 8. Anthony's cyst is in the area called the Triangle of Death. Shane wants to get a lump off his back. Will Brandi's anxiety keep her from getting a lump removed from her chest?

Dr. Sandra Lee assists Diane who has thousands of tumors all over her body, ruining her life. Will fears his shoulder lump will be ripped open at work, Anthony's daughters force him to get his lump examined and Kal-Elle detests her hideous varicose veins.

Belinda's lump on her neck causes her to basically be immobile. Nicole won't get married until she gets her arm pit lump removed. Adela's chest and back are covered in wisdom spots and Nick foolishly removed a lipoma at home and now needs Dr. Lee's help.

Taylor has a large bump at the base of her spine that is far more dangerous than she realizes. John jokes about hip lump, but turns out it's no laughing matter. Noelle had her ears stretched as a teenager, but now wants them repaired.