Jimmy Kimmel Live

In the premiere episode, we learn about the life of Mary Alice and the company she kept on Wisteria Lane.

The ladies find an anonymous letter in Mary Alice's belongings which suggest that Mary Alice was hiding some terrible secret; Susan and Edie continue to fight for Mike's affections.

The four ladies decide to organize the dinner the late Mary Alice was organizing. Gabrielle is blackmailed by a 9 year old girl, Bree tries to hide a broken marriage and Karl returns to Wisteria Lane to discuss terms with Susan.

Cash-strapped Mrs. Huber figures out that Susan had something to do with Edie's house fire and tries to blackmail her; Carlos becomes suspicious that Gabrielle is seeing another man, but targets the wrong suspect.

A break-in on Wisteria Lane leaves the neighbors feeling vulnerable, especially Susan, who reluctantly accepts a date with persistent police officer Rick Thompson, after Mike Delfino appears indifferent to her.

Lynette locks horns at the twins' school with officious mom Maisy Gibbons, who is trying to produce a politically correct play about Little Red Riding Hood.

Susan is miffed when Mike gets an unexpected house guest, which forces him to postpone their first official date. Lynette becomes steadily more dependent on the twins' A.D.D. medication.

After their son Andrew accidentally runs over Carlos' mother Juanita Solis, Bree and Rex help Andrew cover the incident up by disposing of the car and the evidence.

Gabrielle decides to organize a glamorous Halston fashion show for charity highlighting the ladies of Wisteria Lane; Susan learns Gabrielle's adulterous secret.

Uber-mom and control freak Maisy Gibbons returns, and her secret life of being a call-girl intersects with Bree's when she finds out that Rex is cheating on her.

Edie organizes a neighborhood search for the missing Mrs. Huber, just as the absent annoying and busybody's sister, Felicia Tilman, arrives on Wisteria Lane to investigate her disappearance.

The residents of Wisteria Lane finally learn Martha Huber's fate when her body is discovered, and the truth has unexpected consequences for Susan.

When Lynette's father-in-law, Rodney Scavo, visits Tom's family, she unwittingly learns a family secret: he's been consistently cheating on his wife, and Tom has known about it.

While breaking into a neighbor's house in his continuing search for clues, Mike gets shot by the jittery owner, and tries to hide it from Susan during their dinner out.

Mike is arrested for questioning about Mrs. Huber's murder by police after Lynnette shares her suspicions about him. Susan, refusing to believe the accusations, gets Mike freed by claiming that they were together the night of Mrs. Huber's disappearance.

Maisy Gibbons shocks the residents of Wisteria Lane when she is arrested for solicitation right out of her own house. When Maisy's little black book becomes public, Rex is outed as a client.

Mama Solis finally awakens from her coma but will she tell anyone about her knowledge of Gabrielle's affair with John?

Susan's neurotic and obnoxious mother pays an unannounced visit after she and her boyfriend call it quits.

Lynette learns that no good deed goes unpunished when she momentarily befriends the elderly, mean-spirited Mrs. Karen McClusky after saving her life, but later regrets it when Mrs. McClusky will not leave her alone.

Gabrielle plans a big party to bid farewell to Carlos before he begins his jail sentence. Meanwhile, George Williams returns, much to Rex's displeasure.

Psycho pharmacist George Williams continues to worm his way into Bree's life by asking her out to dinner. After Edie spies on Bree with George at a restaurant, Bree begins to feel guilty about sharing intimate feelings with George.

Lynette takes steps to make sure Annabel doesn't come between her and Tom, and the consequences make Tom lose his job. Bree comes to a realization about George who continues to interfere in her and Rex's lives.

Bree and Rex make amends but tragedy hits the Van De Kamp family again; Edie meets the new residents of Wisteria Lane; Gabrielle testifies for Carlos; and Tom decides what to do with his life.